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When do you consider the use of an MAOI in treatment-resistant major depressive disorder?

What clinical features or patient characteristics lead you to consider an MAOI? How do concerns about safety, dietary restrictions, drug interactions, or access impact your decision-making?
2 Answers
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Psychiatry · South Broward Hospital District
Answered on

MAOIs can be great in treatment-resistant depression, but after you explain how there might need to be some dietary restrictions, patients generally refrain from wanting to try them. To be frank, the dietary restrictions are overblown (A concise guide to monoamine oxidase inhibitors). There are 2 pa...

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Mednet Member
Mednet Member
Psychiatry · St. Clair Hospital
Answered on

Some 20 years ago, one of my patients disclosed to me that while taking Parnate (tranylcypromine), she had been deliberately consuming cheese - particularly Roquefort and Gorgonzola and drinking sherry nightly, planning to tell emergency services "as I was diying'' that "Dr. Spina never told me of a...

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