When do you consider total neoadjuvant therapy (chemotherapy and chemoradiation) for rectal cancer?

My practice, and that of my group, has moved more towards a TNT model for stage II and III patients, though I think we are all looking for the PROSPECT data to be finalized. NCCN has adopted TNT as a possible consideration, and other groups are considering this more and more (Cercek et al, Jama Onco...