Mednet Logo

When do you consider using dextromethorphan–bupropion for the treatment of depression?

In which clinical situations do you find it most useful? How do you decide between dextromethorphan–bupropion (Auvelity) and bupropion alone? What barriers have you encountered (e.g., cost, insurance coverage, or tolerability)? Have you observed differences in onset of action or outcomes compared to other antidepressants?
1 Answer
Mednet Member
Mednet MemberInvited Expert
Psychiatry · Wayne State University School of Medicine
Answered on

The data support a rapid antidepressant effect given the NMDA activity that is different than monoamine activity of all other antidepressants. Within a week, many patients I treat notice a benefit and this continues to improve for several weeks. The general guidelines would suggest Auvelity be a sec...

Join for free or sign in to see the full answer