When do you find benefit in sequencing different dopamine receptor blockers for emergency treatment of migraine?

I do not think that intravenous dopamine-receptor antagonists provide a specific migraine-abortive benefit. They either cause drowsiness, which may be helpful to the patient in terms of inducing sleep, or cause akathisia that makes the patient want to leave the emergency room as soon as possible. At...

Prochlorperazine has the strongest evidence of efficacy for IV acute treatment of migraine disorder. I have not routinely switched to metoclopramide IV if prochlorperazine was not effective. I am not aware of specific studies to guide this answer.

We do switch treatments within the same class when i...