When do you offer radioembolization (Y90) in the treatment of unresectable HCC?

Y90 does have some more data of better LC than TACE but not with OS in the Brown meta analysis (Brown et al., PMID 35943116).

I think for small tumors less than 5 cm, Y90 can be appropriate. I would not treat it for PVTT. The SARAH trial had a large majority with PVTT and was negative. As were Sorem...