When do you pursue MRI iron quantification for elevated ferritin with normal TSat, and when do you consider rare diagnoses like ferroportin disease or aceruloplasminemia?
Are there specific ferritin/TSat thresholds, trends, or clinical features that prompt further investigation? How do you balance avoiding unnecessary workup with the possibility of clinically significant tissue iron deposition despite a normal TSat?
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In patients with persistent hyperferritinemia without elevated transferrin saturation, what findings would prompt you to obtain MRI-based liver iron quantification?
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1 Answer
Mednet MemberInvited Expert
Pediatric Hematology/Oncology · Weill Cornell Medical College
Answered on
Serum ferritin is an acute-phase reactant, so it can often be elevated without true iron overload, especially in the setting of viral illnesses or other inflammatory events. It is best not to do the test when something like that has occurred in the past 3-4 weeks or so. Overnight fasting is key to t...
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