It's a really great clinical question but, unfortunately, driven just as much by anecdotal practice as by objective data. Calcineurin inhibitors such as tacrolimus (Tac) and cyclosporine (Csp) work by mechanisms that ultimately lead to a decrease in T cell activation. As CD8+ T-cells play a major p...

I'd agree with this. We have also been using tacrolimus as an additional agent and the advantage is that it can be combined with the other usual DMARDs for extra help. One scenario where we are reaching for it more frequently is in the realm of ILD, especially related to MDA5 given the beneficial st...