When do you recommend consolidative XRT for patients with advanced stage (III-IV) DLBCL who achieve CR to chemoimmunotherapy?

The cornerstone of therapy for advanced DLBCL is chemoimmunotherapy (R-CHOP). Efforts to improve upon this with systemic therapy have been largely unsuccessful (dose-dense chemotherapy, maintenance R, more intensive chemotherapy, high-dose chemotherapy and autologous SCT, etc.). There are increasing...

In 31 years of practice, I have never seen a case with III-IV presentations and limited disease extent in which all sites of disease can be safely encompassed. Even if they existed, I believe no data exists to support RT in this setting, either as an addition to systemic therapy, or instead of syste...