When do you recommend preop RT for retroperitoneal sarcomas?

I imagine I'm not alone in feeling a tad frustrated with the STRASS trial results, not because of the negative primary endpoint in regards to radiotherapy, but because it failed to clearly answer the question it was supposed to.

In brief, the STRASS trial was a 2-arm randomized controlled trial of su...

The STRASS study of surgery versus RT + surgery had obvious impact on our field. I think it is good, however, to keep in mind the limitations of the study and the reported outcome at this time (ACRO meeting 2020 - Sarcoma session, DeLaney et al., PMID 33387499). I look forward to the continued outco...

STRASS did not show "no benefit" from preop RT. On the contrary, every piece of data we have--including STRASS--suggests about a 50% reduction in local recurrence rates with preop RT for STS. That number is remarkably consistent across studies.

These studies include:

1. STRASS itself, appendix p6 and...