When do you refer AYA patients with newly diagnosed severe aplastic anemia for transplant?  

In a young person, my first thought is to obtain telomere lengths to be sure he/she does not have a telomeropathy. This has significant implications both with and without transplantation. Certainly, if telomeres are short, allogeneic transplantation is preferred since there is less likelihood of res...

Telomere length determination is certainly important, as the dyskeratosis congenita phenotype is often incomplete and implications of telomeropathy on transplant conditioning are important, as Dr. @Antin indicates. However, that is not the whole story. I would recommend a much broader evaluatio...