When do you use neoadjuvant endocrine therapy for postmenopausal women with ER positive early stage breast cancer?

I think that neo-adjuvant endocrine therapy is an excellent option particularly for post-menopausal women with strongly ER/PR + cancers who are marginal candidates for breast conservation. I will generally consider for those women who don't have any characteristics that I think would require chemotherapy, or I will send a test like Mammaprint upfront and if low risk, would not use chemotherapy in that patient. I think the important thing to keep in mind is that responses are less robust and take...