Although off-label and not included in guidelines, olanzapine can be helpful for migraine attacks in the ER and even for prevention in chronic migraine that has failed all other treatments. 10 mg is usually given IM and 2.5 or 5 mg IV. The MOA is probably as a dopamine antagonist and it is often use...
I use olanzapine 2.5 mg at night as needed if a headache is not aborted with a first- or second-line therapy such as a triptan/gepant and NSAID. Due to a potential side effect of drowsiness, I have recommended taking it at night. Also, I use olanzapine as a cycle breaker or bridge therapy, usually 2...
No, I don't. I only use migraine-specific medications. As far as I am concerned, that is the standard of care. Ergots, triptans, and gepants abortively, and CGRP-antibodies and gepants preventively.