I tend to use rozanolixizumab in a few different situations for MuSK myasthenia. The obvious one is when patients have a significant bulbar weakness that needs to be controlled ASAP. Aside from that, I may try rozanolixizumab in patients who do not respond well to prednisone, primarily to get them b...
Rozanolixizumab is unique in that it is the only FDA approved treatment for both AchR and MuSK autoantibody (+) MG and works by reducing total IgG levels, including IgG4. MuSK (+) MG is mostly a pathogenic IgG4-mediated disorder with direct inhibition of protein interactions and damage of the post-s...
It is a first-line drug for me for MG due to MuSK ab, as the MycarinG trial showed a benefit, and it has an indication from the FDA for this condition.