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Topics:
Neurology • Vascular Neurology
When do you use tirofiban for acute ischemic stroke?
In light of recent trials - Tao et al., PMID 40616232
Answer from: at Academic Institution
Early tirofiban infusion after IV thrombolysis makes sense for acute strokes due to intracranial stenosis. As an endovascular specialist, I have often seen MCA or basilar occlusions reopen with IV thrombolysis but only to reocclude when there is an underlying severe atherosclerotic lesion. My approa...
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Answer from: at Community Practice
I agree with the prior post. This study appears to target acute ischemic stroke due to intracranial atherosclerotic disease (ICAD) etiology, where tirofiban (or other antiplatelet infusions) administered post-thrombolytics make mechanistic sense.
ICAD occlusions are "hot lesions", driven by active ...