When do you utilize lenalidomide in patients with MDS without del(5q)?

Lenalidomide is beneficial in low-risk and int -1 risk MDS patients with anemia even without del 5q in combination with EPO as shown in ECOG 2905 study.

List et al., PMID 33439748

These low-risk MDS tend to be MDS with refractory anemia and ringed sideroblasts.

MDS RS with thrombocytosis tends to be re...