When giving total neoadjuvant therapy for rectal cancer, do you sequence radiation and chemotherapy differently depending on the tumor distance from the anal verge?

With all of the emerging data in rectal cancer and, particularly, if considering non-operative management, I think it is crucial to discuss these patients as part of a multidisciplinary team now more than ever. Prior to starting any therapy, we try to ensure that all of our newly diagnosed rectal ca...

That’s a great question, and I’m not sure that it is one that we have the answer to quite yet. When we started treating patients with TNT, we favored starting with chemotherapy first similar to the strategy used in NRG-GI002. With the newer data from studies like OPRA and RAPIDO, we transitioned to ...

Agree with Dr. @Dr. First Last's response to the two question combination and the need for patients to be seen by all 3 specialties before initiation of any treatment (RadOnc, MedOnc, colorectal surgeon).

However, question 2 does not allow a complete discussion of the issues raised in question 1 "Whe...