When, if ever, would you consider lenvatinib + pembrolizumab as first line therapy for patients with stage IV microsatellite stable endometrial cancer?

Topics: Gynecologic Cancers • Endometrial Cancer • Medical Oncology • Journal Club ft. NEJM publications

Are there certain patient or disease related factors that would lead you to incorporate lenvatinib + pembrolizumab earlier?

Answer from: at Community Practice

Outside of a clinical trial, I have not incorporated lenvatinib and pembrolizumab therapy as 1L therapy for pMMR endometrial cancer patients. This question will be answered by the LEAP-001 trial, which has completed accrual.

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