Please select the option that best describes you:
When, if ever, would you consider methotrexate over prednisone for first line therapy in patients with pulmonary sarcoidosis?
Do the findings of the PREDMETH trial influence your approach?
Answer from: at Academic Institution
The PREDMETH trial supports the use of methotrexate for initial therapy for sarcoidosis. Future studies may identify subgroups that may benefit from the concurrent use of prednisone initially; it is unclear how soon methotrexate may provide symptomatic relief compared to the ability of an appropriat...
Sign In or Register to read more
Answer from: at Academic Institution
The PREDMETH trial supports Dr. Baughman's original report over 20 years ago that methotrexate may be useful for long-term management of pulmonary sarcoidosis in a subset of patients; the perceived efficacy may depend on dosing. Overall, the study supports an approach to sarcoidosis akin to the mana...