When, if ever, would you consider methotrexate over prednisone for first line therapy in patients with pulmonary sarcoidosis?
Do the findings of the PREDMETH trial influence your approach?
Answer from: at Academic Institution
The PREDMETH trial supports the use of methotrexate for initial therapy for sarcoidosis. Future studies may identify subgroups that may benefit from the concurrent use of prednisone initially; it is unclear how soon methotrexate may provide symptomatic relief compared to the ability of an appropriat...