When interpreting a 24-hour urinary calcium, which is more accurate: 24 hour urine calcium (mg/day) or 24-hour calcium-to-creatinine ratio (mg/g)?  

In my opinion, the answer is unequivocal, i.e. calcium to creatinine ratio is the only way to interpret a 24-hour urine calcium. It is essentially impossible to collect an exact urine sample of 24 hours. The only way to do this, which is often unrealistic, is for the patient to empty the bladder and...

I agree with Dr. @Holick's comments. In my experience, one of the most challenging aspects of the 24-hour urine collection is the 24-hour urine collection! It is clearly the standard protocol, and I always use it. Explaining to the patient how to collect the 24-hour urine is essential. Also, it is i...