When is a bone marrow biopsy indicated in the up-front evaluation of an AYA patient with Ewing sarcoma?

In general, I would not recommend a different approach to the initial staging evaluations for an AYA with a new diagnosis of Ewing sarcoma vs a younger child or an older adult.

Although the standard approach that is most widely accepted would be to perform a bone marrow evaluation for all patients w...

Bone marrow aspirate/biopsy (BMA/B) is routinely performed in the upfront staging of newly diagnosed patients with Ewing sarcoma (EWS) and has been a requirement in the most recent EWS clinical trials through the Children's Oncology Group which included patients up to age 50. At this time, we have n...