When is it too far out from CRT to the chest to be considered for PCI for limited-stage SCLC?
What is the ideal time window for delivering PCI for LS-SCLC?
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How about this answer that was not listed - "don't give it!"
The evidence we hang our hat for PCI in SCLC is not just weak, it is also outdated. With the medical technology available they had at the time, it made logical sense that staging would miss brain metastases. ~50% of the studies in the meta...
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I've often wondered this myself, and there's no clear evidence or guideline to my knowledge. One reference point is the EORTC trial of PCI in extensive stage SCLC, which mandated that PCI start 4-6 weeks after chemo. But probably the best way to think about this is, during what period are brain meta...
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No limit as long as no brain Mets.
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