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Genitourinary Cancers • Bladder Cancer • Medical Oncology • Urologic Oncology • Journal Club ft. NEJM publications
When is the ideal time to start adjuvant nivolumab after radical surgery in urothelial carcinoma?
Is a 3 month delay too long in someone who had postoperative complications?
Answer from: Medical Oncologist at Community Practice
In the reported and ongoing adjuvant therapy trials, patients must have had radical surgery (R0, with negative surgical margins) within 120 days before randomization. However, it is biologically rational to target initiating therapy as soon as he/she is fit for nivolumab following surgery (data in t...
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Answer from: Medical Oncologist at Academic Institution
In CM274, patients were required to be randomized within 120 days of surgery. Initiation of treatment once a patient has recovered from surgery is reasonable, but this window was allowable as per CM274 eligibility.