When is the ideal time to start adjuvant nivolumab after radical surgery in urothelial carcinoma?

In the reported and ongoing adjuvant therapy trials, patients must have had radical surgery (R0, with negative surgical margins) within 120 days before randomization. However, it is biologically rational to target initiating therapy as soon as he/she is fit for nivolumab following surgery (data in t...

In CM274, patients were required to be randomized within 120 days of surgery. Initiation of treatment once a patient has recovered from surgery is reasonable, but this window was allowable as per CM274 eligibility.