When MGUS is suspected in a patient with one risk factor and no evidence of end-organ damage, what additional workup should be done, if any?
Risk factors include: non-IgG subtype, abnormal serum light chain ratio, M-protein >=1.5 mg/dL.
Further work up could include imaging, bone marrow aspirate and biopsy, etc.
1 Answer
Mednet Member
Medical Oncology · Los Angeles VA Medical Center
Answered on
My approach applies only for the scenario of thinking about monoclonal gammopathy -> myeloma spectrum. Monoclonal gammopathy -> amyloidosis or MGRS/MGNS, etc. I think of quite differently.
Our VA pathways and other organizations have advocated for bone marrow biopsy in this situation. For example, in...
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