When should amblyopia treatment be initiated in patients being treated for retinoblastoma?

There is decent data (small numbers) that amblyopia therapy is beneficial in RB patients, even those with macular/foveal involvement if this is unilateral. The timing for initiation is not clear, however. Treatment initiation is probably most effective once tumor burden is under control enough to have viable retina visible. And of course, once the family is not overwhelmed by the initial diagnosis and ready to think about the next steps in vision preservation.