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When should MOG-Ab be tested in patients with suspected autoimmune encephalitis with seizures and normal MRI?

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Mednet Member
Mednet Member
Neurology · The University of Iowa

In someone with suspected autoimmune encephalitis with seizures and a normal MRI (presuming done with gadolinium and the optic nerves are well visualized), I would not obtain MOG. MOG testing would have a very low pretest probability (so low that a positive test might well be a false positive). If o...

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Mednet Member
Mednet Member
Neurology · Case Western Reserve University

In my opinion, it should be tested. MOGAD phenotype is expanding. I have recently seen a MOG Ab+ case presenting with encephalitis, seizure, and a normal MRI, abnormal PET brain.

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