When should MOG-Ab be tested in patients with suspected autoimmune encephalitis with seizures and normal MRI?
In light of how MOG-Ab is excluded on panels like Mayo ENS2.
2 Answers
Mednet MemberInvited Expert
Neurology · The University of Iowa
Answered on
In someone with suspected autoimmune encephalitis with seizures and a normal MRI (presuming done with gadolinium and the optic nerves are well visualized), I would not obtain MOG. MOG testing would have a very low pretest probability (so low that a positive test might well be a false positive). If o...
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Mednet MemberInvited Expert
Neurology · Case Western Reserve University
Answered on
In my opinion, it should be tested. MOGAD phenotype is expanding. I have recently seen a MOG Ab+ case presenting with encephalitis, seizure, and a normal MRI, abnormal PET brain.
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