When should proton beam therapy be considered for uveal melanoma?
Are there exclusion criteria?
Answer from: Radiation Oncologist at Academic Institution
When the tumor is identified as COMS large or the patient is not in favor of enucleation, and or plaque therapy is not feasible due to location. Tumors located in the back of the eye and under orbital muscles are difficult to treat with plaque without significant risk to the muscles or nerves. The s...
Sign in or Register to read more
Answer from: Radiation Oncologist at Academic Institution
Apart from proton therapy, SRS and SRT have also been shown to yield similar outcomes. SRS and SRT will be invaluable for patients with no or limited access to protons. There are numerous studies in the literature showing efficacy and acceptable toxicities.References:Yazici et al. IJROBP 2017Krema e...
Answer from: Radiation Oncologist at Academic Institution
1. Proton/particle therapy can and has been used for all T-stages (COMS small, medium, and large uveal melanoma tumors). There are no particular exclusions based on size, extent, location.
2. 95-98.9% Local controlIn meta-analyses, prospective, and retrospective published data, 5y LC has be...