When should proton beam therapy be considered for uveal melanoma?

When the tumor is identified as COMS large or the patient is not in favor of enucleation, and or plaque therapy is not feasible due to location. Tumors located in the back of the eye and under orbital muscles are difficult to treat with plaque without significant risk to the muscles or nerves. The success of proton treatments is derived from data: >5,000 patients treated with a 5-year local control of 98% and 95% for small/medium and large ocular melanomas, respectively.

The overall 5-year metast...

Apart from proton therapy, SRS and SRT have also been shown to yield similar outcomes. SRS and SRT will be invaluable for patients with no or limited access to protons. There are numerous studies in the literature showing efficacy and acceptable toxicities.

References:

Yazici et al. IJROBP 2017

Krema et al. B J Oph 2013

Suesskind et al. JAMA Oph 2013