When should surgical tumor resection be considered in patients with a low-grade glioma?

In adults with low-grade gliomas, there is substantial evidence suggesting that aggressive, early surgical resection improves outcomes and survival (Jakola et al., PMID 23099483). Historically, this has been particularly true for tumors that carry an IDH mutation or 1p/19q codeletion. This survival benefit seen after surgical resection is likely because of the high risk of malignant transformation in adult low-grade gliomas. The new availability of targeted medications, such as vorasidinib, may ...