When treating with SBRT and immunotherapy for unresectable HCC, how do you sequence the treatment?

Data are scattered, with some starting concurrent and some starting after SBRT to optimize the priming of the immune system with RT.

Answer from: Radiation Oncologist at Academic Institution

Great question. No great data in this space regarding optimal sequencing. In general, I would sequence SBRT first, followed by initiation of immunotherapy. Some data suggest that SBRT may best prime IO if administered prior to IO. Additionally, if the IO regimen preferred is atezolizumab/bevacizuma...

Comments

Radiation Oncologist at Fox Chase Cancer Center
I agree with Dr. @Wo, with the caveat that there a...

Medical Oncologist at Dartmouth Cancer Center, Dartmouth-Hitchcock Medical Center
We have struggled with this question in our liver ...

Radiation Oncologist at Massachusetts General Hospital
Agree with Dr. @Brooks. We typically consider the ...

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When treating with SBRT and immunotherapy for unresectable HCC, how do you sequence the treatment?

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