When using Quad Shot regimen for palliation of unresectable head and neck cancers, would you treat concurrently with chemotherapy?

No. If palliative RT, I usually don’t recommend concomitant chemo.

At Beth Israel, we treated patients with Quad Shot fraction with the addition of radiosensitizing carboplatin. Carbo AUC2 was administered on day 1 of each "cycle,"Q3w. Compared to data from quadshot alone, we noted improved objective response, CR and PR rates and all patients noted palliation of th...