When would you consider gemcitabine/cisplatin with Y90 for patients with unresectable intrahepatic cholangiocarcinoma ?

There is very limited data supporting the gemcitabine/cisplatin chemotherapy together with Y90 for treatment of unresectable intrahepatic cholangiocarcinoma (ICC). Existing studies of this combined approach (such as PMID: 31670746) report small single-group studies, and there are essentially no comp...