When would you consider initial induction chemotherapy (e.g. FOLFOX) followed by neoadjuvant chemoradiation, over neoadjuvant chemoradiation alone, in patients with locally advanced rectal cancer?
Answer from: Radiation Oncologist at Academic Institution
At MSKCC, we now routinely recommend induction chemotherapy (8 cycles of FOLFOX) to any rectal cancer patient who requires preoperative chemoRT. Initially, we adopted this approach for patients with particularly bulky or node-positive disease (as per @Autumn J. McRee's answer above) but now do it fo...
Comments
Medical Oncologist at Cancer Care Specialists/Renown Oncology/UNR Will you skip chemo XRT if they achieve good trea...
Radiation Oncologist at Memorial Sloan Kettering Cancer Center No, we would not offer that, and we emphasize to p...
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Will you skip chemo XRT if they achieve good trea...
No, we would not offer that, and we emphasize to p...
When would you consider watch and wait following s...