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What is your next step in patient with suspected MG who tests negative for standard ELISA AChR and Musk antibodies?
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1 Answer
Mednet MemberInvited Expert
Neurology · University of Minnesota
Answered on
I will usually recheck in 1-2 years, but I mostly focus on acetylcholine receptor antibodies. I have never seen seroconversion from MuSK negative to MuSK positive.
Also, if initial antibody testing for Acetylcholine receptor binding/modulating and MuSK antibodies is negative by RIA assay, I recommend testing them by cell-based assay. CBA for MuSK antibodies is done by several labs. CBA for AChR antibodies in the US is offered for clinical (non-research) testing only through one lab that I am awa...
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