When would you treat patients with esophageal adenocarcinoma with neoadjuvant chemotherapy alone such as detailed in the UK MRC OE05 trial?  

Taking into account the overlap between treatment regimens for esophageal and gastric cancers, in what clinical context might you feel comfortable treating patients with neoadjuvant chemotherapy alone and avoid post-operative treatment? Would an R0 resection and complete pathologic response be sufficient? Would any residual disease prompt some adjuvant treatment?



Answer from: Medical Oncologist at Academic Institution
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Medical Oncologist at Wenatchee Valley Med Center
Did the trial exclude Siewert 1 and 2? is that wh...
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Answer from: Medical Oncologist at Academic Institution