When would you use acalabrutinib in combination with obinutuzumab vs acalabrutinib alone in upfront CLL treatment?
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When do you add obinutuzumab to BTKi for treatment of CLL (without del(17p)/TP53 mutation)?
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1 Answer
Mednet MemberInvited Expert
Medical Oncology · Long Island Jewish Medical Center
Answered on
I generally prefer acalabrutinib for treating CLL.
When this is first-line therapy and there is a need to give “fixed-duration" treatment, I use obinutuzumab + acalabrutinib.
If this is a single agent (monotherapy), I use Acalabrutinib alone.
For 2nd or 3rd line, if the patient previously has had chem...
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