When you use selinexor for relapsed/refractory myeloma, with what total weekly dose do you practically start?
If tolerated through Cycle #1, how aggressively do you try to titrate the selinexor dose up toward 100mg weekly or 80mg twice-weekly?
And does your answer change based on the regimen, e.g. seli-Kd (with carfizomib) vs seli-Pd (with pomalidomide) vs seli-Vd (with once-weekly bortezomib as in BOSTON)?
1 Answer
Mednet MemberInvited Expert
Medical Oncology · University of Chicago
Answered on
The answer is it depends.
For most older or more frail adults, I would start at 60 mg weekly. For more robust, 80 mg weekly.
More important, is whether I am combining with another anti myeloma agent other than steroids. In that case, I typically stick with 60 mg weekly. This helps not only with non-...
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