When would you use rusfertide to treat polycythemia vera?

I think of rusfertide as being a very effective adjunctive therapy for patients with PV who are on cytoreduction and still requiring phlebotomy!

Given the impact of inducing a molecular response when using a cytoreductive therapy in the treatment of PV, as has been seen across a variety of studies, ...

This is an interesting question, as the FDA only approved rusfertide (Mimrylo) just a few days ago based on the results of the VERIFY trial- a double-blind, placebo-controlled RCT (n=293). Patients were allowed to continue standard-of-care therapy; about 40% of patients continued hydroxyurea, but a ...