Which calculators, nomograms, or other resources, if any, do you use to help advise and prognosticate patients with newly diagnosed glioblastoma or other gliomas?

This is a rather difficult question to answer because prognosis in patients with glioblastoma (GBM) is best estimated by combining several clinical, molecular, radiographic, and treatment-related factors rather than relying on any single variable. Several validated prognostic models exist, but in clinical practice I am often surprised by the variability observed in the survival of these patients.

In clinic, one of the simplest and most informative approaches is to combine:

1. Age
2. KPS
3. MGMT promoter m...

I think it is important to know the average prognosis for methylated versus unmethylated disease (in Stupp, median OS for MGMT methylated was ~ 21 months vs 12 for unmethylated), but there is not a nomogram or algorithm specifically that I use to prognosticate. I emphasize routinely to patients that there is significant individual heterogeneity in clinical course, even if the overall nature of the disease remains aggressive and incurable. Things like location, symptoms, EOR, comorbidities, and p...