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Which method provides a more accurate assessment of hypercalciuria: 24-hour urinary calcium excretion or the spot urine calcium-to-creatinine ratio?
Answer from: at Community Practice
24-hour urine should be more accurate. F. Singer
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Answer from: at Academic Institution
A spot urine for calcium measurement is markedly inferior to the 24-hour urinary collection. The circadian dynamics or urinary calcium excretion, related to food intake and minute to minute variability in calcium regulating hormones, like PTH and 1,25-dihydroxyvitamin D, make the spot urine unreliab...