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Which molecular biomarkers do you favor to risk stratify patients (without CV risk factors) before and after undergoing treatment with cardiotoxic cancer treatments?

1 Answer
Mednet MemberInvited Expert
Cardiology · University of Texas Southwestern Medical School
Answered on

In general, troponin, NTproBNP or BNP, and lipid panel are the main biomarkers I use for CV risk stratification prior to cancer therapy. Baseline troponin and NTproBNP are primarily useful for cancer therapies that may cause cardiomyopathy or myocarditis (i.e. anthracyclines, anti-HER2 therapies, VEGF signaling pathway inhibitors, proteasome inhibitors, immune checkpoint inhibitors, CAR-T). Patients with baseline biomarker abnormalities should be started on cardioprotective therapies (i.e. beta-...

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