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Which novel immunomodulatory treatment(s) do you consider in refractory seronegative bulbar-predominant myasthenia?

Presuming failure/intolerance of steroids, MMF, azathioprine, maintenance IVIg
1 Answer
Mednet Member
Mednet MemberInvited Expert
Neurology · University of Minnesota
Answered on
  1. Re-evaluate the diagnosis. Acetylcholine receptor and MuSK antibody-negative myasthenia with prominent bulbar symptoms, refractory to all the agents mentioned (steroids, MMF, AZA, IVIG) is an extremely rare scenario. Differential diagnosis includes bulbar onset ALS and numerous myopathies (e.g. IBM...

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