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Which other GLP-1 R agonist, if any, would you consider re-trialing in patients who had severe gastrointestinal side effects with Ozempic?

2 Answers
Mednet Member
Mednet Member
Endocrinology · Beth Israel Deaconess Medical Center Division Of Endocrinology

I am curious if you mean someone who has not tolerated the lowest dose of Ozempic, or higher doses. I have had patients who have not tolerated semaglutide but who can tolerate tirzepatide (or dulaglutide or even liraglutide if a daily injection is OK). I have also used "click counting," which is uni...

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Mednet Member
Mednet Member
Endocrinology · McGill University

This question comes up often. GLP1RAs are a class with benefits to ASCVD risk, steatosis, and can offer renal protection as well as support weight management.

Prior to exploring rechallenge, I would make sure there is no other gastrointestinal pathology, for example, underlying gastroparesis, ulcer ...

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