Which patients with mild cognitive impairment do you consider referring for amyloid-targeted therapy?
Were there any specific findings from the TRAILBLAZER-ALZ 2 trial that influenced your approach to patient selection among those with mild cognitive impairment?
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Which factor(s) do you weigh most heavily in considering whether to refer older patients with MCI likely due to Alzheimer's pathology for potential amyloid-targeted therapy?
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2 Answers
Mednet MemberInvited Expert
Geriatric Medicine · Wake Forest University School of Medicine
Answered on
This is an important question, as clearly, not everyone with MCI is appropriate or interested in Amyloid-Targeted Therapy. In general, I would say that the TRAILBLAZER-ALZ 2 trial did not change my approach to patient selection much, but it did provide more evidence that this class of drugs has a pl...
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Mednet MemberInvited Expert
Geriatric Medicine
Answered on
I am of the Aricept era of trials and trubulations… with these new opportunities for treatment of this debilitating disease for patients, families, and communities, I would offer some thoughts that we do not typically think about or train in, but do come to play and often cause additional agita in c...
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