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Which patients with relapsed/refractory NHL are appropriate for pre-CAR-T bridging radiation therapy?

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Which patients with relapsed/refractory NHL would you potentially offer pre-CART bridging radiation therapy?

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2 Answers
Mednet Member
Mednet Member
Radiation Oncology · Mayo Clinic
Answered on

Before answering this important question, I think that we, as Radiation Oncologists, should give serious consideration to moving past the terminology of "bridging radiation therapy" and instead refer to it as "pre-CAR-T infusion radiation therapy." Bridging therapy was initially an apt name; we were...

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Mednet Member
Mednet Member
Radiation Oncology · The University of Texas MD Anderson Cancer Center
Answered on

Bridging radiotherapy is appropriate/beneficial for patients who present with:

  • Rapidly progressive disease that needs to be controlled during the CAR-T manufacturing period (3-6 weeks). Lymphoma at this stage is chemoresistant but radiosensitive. There are studies that show bridging radiotherapy to ...

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