Which patients would benefit most from teplizumab therapy to delay the onset of T1DM?
Herold et al., PMID 31180194
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Would you consider using teplizumab for adults diagnosed with latent autoimmune diabetes in adults who are not on insulin but test positive for one antibody?
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2 Answers
Mednet MemberInvited Expert
Endocrinology · Brigham And Womens Hospital Endocrinology
Answered on
First, for full disclosure, I am an adult endocrinologist and I have not prescribed teplizumab so what I will say is what I have distilled from reading the literature and discussing this topic with colleagues.
Teplizumab was approved for use in a very narrow category of patients with a relatively sma...
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Mednet MemberInvited Expert
Endocrinology · Tufts Medical Center Physicians Organization
Answered on
The presence of HLA-DR4, absence of HLA-DR3, and absence of anti-zinc transporter 8 antibody predicted a response to teplizumab to delay the onset of stage 3 type 1 diabetes.
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