Which patients would benefit most from teplizumab therapy to delay the onset of T1DM?

First, for full disclosure, I am an adult endocrinologist and I have not prescribed teplizumab so what I will say is what I have distilled from reading the literature and discussing this topic with colleagues.

Teplizumab was approved for use in a very narrow category of patients with a relatively sma...

The presence of HLA-DR4, absence of HLA-DR3, and absence of anti-zinc transporter 8 antibody predicted a response to teplizumab to delay the onset of stage 3 type 1 diabetes.