Which regimen is better for gastric adenocarcinoma- neoadjuvant chemotherapy or adjuvant chemoradiation?
Is there a consensus on the MAGIC v. MacDonald debate?
Answer from: Radiation Oncologist at Academic Institution
There are common criticisms of both the MAGIC and INT-0116 trial results.In the MAGIC trial consisting of preoperative (3 cycles ECF) and postoperative (3 cycles of ECF) vs surgery alone, there was inconsistent preoperative staging.. Lymph node dissections were left to the discretion of the surgeon ...
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Answer from: Radiation Oncologist at Academic Institution
The differences in the design of these trials make it impossible to compare the results. Both are viable options. People, and institutions, certainly have preferences for one approach vs. the other, but I would not say there is a consensus.My personal preference is for pre-operative chemoradiation,...