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Which targeted therapies should we be more cautious of giving after recent immunotherapy in NSCLC?

Do you ever consider bridging with chemotherapy, and if so for how long?
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Do you bridge with chemotherapy between a course of immunotherapy and the use of targeted therapy in NSCLC?

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1 Answer
Mednet Member
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Medical Oncology · Roswell Park Comprehensive Cancer Center
Answered on · Updated on

In general, one should be cautious.

Phenomenon of increased toxicity with immune checkpoint inhibitors (ICIs) plus targeted therapies such as EGFR TKI (pneumonitis, hepatotoxicity or dermatologic toxicity), ALK TKIs (mostly hepatotoxicity) or BRAF inhibitors (hepatotoxicity, dermatologic) were obser...

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