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Why are total IgE levels often less than the summation of food allergy component testing?

This can be seen with total IgE or even a specific food where total peanut IgE is less than the sum of the individual components.
1 Answer
Mednet Member
Mednet MemberInvited Expert
Allergy & Immunology · University of Rochester Medical Center
Answered on

I have a couple of thoughts, although the maker would know the best. It may be because the different allergenic proteins (components) are not represented in a perfectly similar concentration in the component test and the total peanut test. In addition, there may be some subtle interference in IgE bi...

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