Topics:
Breast Cancer • Medical Oncology
Why do we give four cycles of TC as adjuvant therapy when some of the clinical trials administered six cycles?
The ABC trials (Blum, JCO, 2017) used six cycles of TC. Is it because of the superiority seen with TC x four cycles versus standard AC x four cycles (Jones, JCO, 2009)?
Answer from: Medical Oncologist at Academic Institution
There are three trials I use to think about this issue: USOR 9735 (TC x 4 vs AC x 4, Jones et al JCO 2009; 27: 1177-1183), ECOG 1199 (AC x 4 with paclitaxel qw x 12, vs taxol q3w x 4, vs docetaxel qw x 12, vs docetaxel q3w x 4, Sparano et al JCO 2015; 33: 2353-2360) and the ABC analysis (TC x ...
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