Do PORTEC-3 and GOG-258 change your approach to managing patients with high-risk or node positive endometrial cancer?
Answer from: Radiation Oncologist at Academic Institution
The ambiguous answer is "yes and no." The positive impact of RT on vaginal and nodal failure rates cannot be ignored and argues for a continued role for RT, probably external RT.
There are a number of caveats relative to the interpretations of GOG 258. These include (but may not be limited to...
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Answer from: Radiation Oncologist at Community Practice
Based on PORTEC 3, there is a limited benefit of chemo in high risk stage I and II disease (similar to GOG 249) and an improvement in outcome for stage III endometrioid disease (randomization was chemo RT vs. RT). GOG 258 for advanced stage shows a significant decrease in locoregional recurrence (28...
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Radiation Oncologist at Varian Medical Systems/Allegheny health network
Another important difference in practice pattern i...
Another important difference in practice pattern i...
Answer from: Radiation Oncologist at Community Practice
We should await final publication of GOG 258, but the results unfortunately will be interpreted as a negative study for combined chemo+RT. This despite the significant locoregional benefit of radiation of 15%It should be noted that while the study is described as having Stage III endometrial cancer...